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butabarbital will minimize the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.diazepam will enhance the amount or impact of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrat